Break most of the icings and start working out from the bottom. Whether during a moon struck or not, plan carefully to make as many colour bombs as possible. Whenever an opportunity for two colour bombs to be combined arises, do whatever you can to bring them next to each other and mix them.
Aside from colour bombs, try not to create other special candies lest they blow up the colour bombs. In addition, any accidental release of large cascades may tip off Odus, or activate colour bombs.